Palouse is a city in Whitman County, Washington, United States. The population was 998 at the 2010 census. Palouse is named for the region of farmland in which it is situated, and was incorporated in 1888.
As of the census of 2000, there were 1,011 people, 432 households, and 288 families residing in the city. The population density was 944.8 people per square mile (364.8/km2). There were 471 housing units at an average density of 440.2 per square mile (170.0/km2). The racial makeup of the city was 95.94% White, 0.99% Native American, 0.30% Asian, 0.99% from other races, and 1.78% from two or more races. Hispanic or Latino of any race were 1.68% of the population.
There were 432 households out of which 31.5% had children under the age of 18 living with them, 53.0% were married couples living together, 10.9% had a female householder with no husband present, and 33.3% were non-families. 28.9% of all households were made up of individuals and 10.9% had someone living alone who was 65 years of age or older. The average household size was 2.34 and the average family size was 2.